The second part of this 2-part series on infectious disease, “Part 2: Indolent Head Scratchers,” presents cases of patients not in imminent danger, but sick with puzzling symptoms and histories. Some of these cases have a prolonged clinical course, while others are just plain weird. Some cases present with common findings seen every day in clinical practice, but hide something rare and elusive under the surface, which comes into focus as the case progresses. Some of the diagnoses have been missed or overlooked for quite some time, given the indolent nature of the disease and cognitive biases. Available for purchase at https://www.aap.org/Pediatric-Collections-Infectious-Disease-Cases-Part-2-Indolent-Headscratchers-Case-Reports-from