The revised and updated second edition covers practical approaches to caring for healthy and high-risk infants. Available for purchase at https://www.aap.org/neonatalogy-for-primary-care-2nd-edition-paperback/
Chapter 3: Prenatal Diagnosis
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Published:January 2020
Diana S. Wolfe, MD, MPH, Barrie Suskin, MD, FACOG, FACMG, 2020. "Prenatal Diagnosis", Neonatology for Primary Care, Deborah E. Campbell, MD, FAAP
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Fifty percent of early pregnancy losses and 6% to 11% of stillbirths and neonatal deaths are attributed to chromosomal abnormalities.1,2 Nonlethal abnormalities can cause significant morbidity and occur in 0.7% of newborns.3 Although detecting all abnormalities is not possible prenatally, screening and diagnostic tests are available to better establish a risk assessment for a gestation.
Prenatal screening first became available more than 30 years ago and has been evolving ever since. Initially, maternal age and history were the only means of screening available. This practice changed in the mid-1980s when Cuckle and colleagues4 demonstrated that...
