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Approximately 10% of all neonates are born with birth defects. Three percent of all neonates have serious, potentially life-threatening anomalies, and an additional 7% to 8% of neonates are born with minor malformations.1 Advances in prenatal screening, diagnosis, and intervention have contributed to an increased awareness at the time of birth of newborns in need of postnatal evaluation to confirm a prenatal diagnosis. For those newborns with a confirmed prenatal diagnosis, this information permits more rapid initiation of treatment and can help guide the evaluations necessary to optimize care. The patterns of malformations seen among newborns have changed over...

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