The revised and updated second edition covers practical approaches to caring for healthy and high-risk infants. Available for purchase at https://www.aap.org/neonatalogy-for-primary-care-2nd-edition-paperback/
Chapter 24: Neonatal Jaundice
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Published:January 2020
Kathryn A. Johnson, MD, FAAP, Britni B. Maple, MD, Luc P. Brion, MD, FAAP, 2020. "Neonatal Jaundice", Neonatology for Primary Care, Deborah E. Campbell, MD, FAAP
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The term jaundice, derived from the French jaune, meaning yellow, is yellow pigmentation of sclera, skin, and urine caused by hyperbilirubinemia. Jaundice in neonates can be caused by an accumulation of conjugated (direct) or unconjugated (indirect) bilirubin. Most neonatal jaundice is caused by accumulation of unconjugated bilirubin. Degradation of red blood cells releases hemoglobin, which is converted to bilirubin by macrophages in the liver and spleen and released into the plasma. Bilirubin is then bound to serum albumin and transferred to the liver, where it is conjugated to glucuronate via glucuronyl transferase.1 Any process that results in...
