The revised and updated second edition covers practical approaches to caring for healthy and high-risk infants. Available for purchase at https://www.aap.org/neonatalogy-for-primary-care-2nd-edition-paperback/
Chapter 28: The Newborn with Hematologic Abnormalities
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Published:January 2020
Rochelle R. Maxwell, MD, M. Catherine Driscoll, MD, Deepa Manwani, MD, 2020. "The Newborn with Hematologic Abnormalities", Neonatology for Primary Care, Deborah E. Campbell, MD, FAAP
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Evaluating hematologic disorders in newborns is fundamentally different from evaluating hematologic disorders in older children because the developmental aspects of erythropoiesis and hemostasis are not complete at birth. Such development continues throughout much of the first months of postnatal life.
The fetal and neonatal erythrocyte differs from the adult erythrocyte in terms of life span, membrane structure, hemoglobin (Hb) content, and metabolic content. The life span of the erythrocyte is 60 to 80 days in the healthy, full-term infant and 30 to 50 days in the preterm infant,1 which is significantly shorter than the 120-day average life span of...
