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At birth, placental function, including transport of glucose, calcium, phosphorus, and magnesium, is interrupted. Subsequently, the newborn is required to independently regulate these metabolites. Although these processes usually occur uneventfully, the primary care physician should be familiar with the physiologic transition required for homeostasis involving magnesium, calcium, and glucose after removal of the placenta. Hypoglycemia is among the most commonly encountered problems in the nursery and remains an area of controversy.

Glucose is transported to the fetus by facilitative diffusion along a placental concentration gradient. Glucose transport capacity increases with gestational age and glucose serves as the primary fetal fuel,...

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