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Adrenal crisis is a rare but life-threatening emergency, with a high mortality rate, unless recognized and treated promptly. At presentation, adrenal crisis may be a sign of adrenal insufficiency, or it may occur when a patient with known adrenal insufficiency does not receive adequate hormonal replacement. A patient being tapered off chronic glucocorticoid therapy is also vulnerable. Because the signs and symptoms of adrenal insufficiency are nonspecific, the diagnosis may not be suspected until late in the disease course, when the patient presents with a life-threatening cardiovascular collapse or severe hypoglycemia.

Primary adrenal insufficiency is consequent to diseases that affect...

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