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34: Acute Hepatitis
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Published:May 2023
Jennifer Casatelli, MD, FAAP, "Acute Hepatitis", Caring for the Hospitalized Child: A Handbook of Inpatient Pediatrics, American Academy of Pediatrics Section on Hospital Medicine, Jeffrey C. Gershel, MD, FAAP, Daniel A. Rauch, MD, FAAP, SFHM
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Acute hepatitis is defined as inflammatory liver injury in a patient with no previous history of chronic liver disease.
The cause of acute hepatitis in children varies according to age. Overall, when a cause can be identified, a viral etiology is the most common (hepatitis A, Epstein-Barr virus). In a neonate, hepatitis can be multifactorial, and infectious and metabolic hepatitis are more frequent. In children older than 1 year of age, viral hepatitis, drugs, and indeterminate causes are the most common etiologies, followed by autoimmune conditions and Wilson disease (rare). Acetaminophen overdose is an important cause in adolescents that has...
