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Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn disease (CD), cause chronic intestinal inflammation characterized by clinical exacerbations and remissions. Inflammatory bowel disease affects children of all ages. Disease in the first 2 years after birth is referred to as infantile-onset IBD, while very early–onset IBD occurs in patients between 2 and 6 years of age.

Specific symptoms are dependent on the extent and location of inflammation, with significant individual variability in disease severity. Crohn disease can affect any portion of the gastrointestinal (GI) tract but frequently involves the colon and terminal ileum. Ulcerative colitis affects the rectum...

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