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Pancreatitis is an acute, recurrent, or chronic inflammatory condition of the pancreas. Approximately 25% of pediatric cases of acute pancreatitis are idiopathic. Other causes include trauma, systemic illness, structural abnormalities, medications or toxins, infections, and metabolic or autoimmune disorders (Table 41–1).

Pancreatitis can lead to abnormal endocrine or exocrine function, which usually resolves completely. Rarely, it can progress to necrotizing pancreatitis, with potential pancreatic insufficiency. Some patients will have recurrent pancreatitis, with the potential for persistent inflammation and chronic pancreatitis within the ductal system. Severe cases of chronic or hereditary (autosomal dominant) pancreatitis may cause pancreatic insufficiency or...

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