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45: Complications of Cancer Therapy
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Published:May 2023
Caryn A. Kerman, MD, Jason L. Freedman, MD, MSCE, "Complications of Cancer Therapy", Caring for the Hospitalized Child: A Handbook of Inpatient Pediatrics, American Academy of Pediatrics Section on Hospital Medicine, Jeffrey C. Gershel, MD, FAAP, Daniel A. Rauch, MD, FAAP, SFHM
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The survival rate for children with cancer continues to improve but is still associated with significant toxicities and late effects. Chemotherapy, which targets rapidly dividing cells, leads to significant cytotoxic side effects. Although the effects of radiation therapy are more localized, there can be profound consequences, including nausea, vomiting, pain, and skin changes. Surgery can lead to issues with wound care, infection, and pain.
Many chemotherapeutic agents share a number of side effects (see Table 45–1).
Steroids are used in treating pediatric cancers such as acute lymphoblastic leukemia and certain lymphomas, as well as for managing local edema surrounding...
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