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Platelets, also known as thrombocytes, are essential for primary hemostasis. The normal number of platelets in a child is 150,000–450,000/mcL, while thrombocytopenia is defined as platelet count less than 150,000/mcL. Bleeding signs and symptoms become apparent when the platelet count is less than 50,000/mcL, and severe thrombocytopenia is less than 20,000/mcL.

Thrombocytopenia can be secondary to either increased destruction or decreased production. There is a greater likelihood of a serious disorder if the thrombocytopenia is associated with neutropenia and anemia.

In the acute inpatient setting, thrombocytopenia may present with evidence of a bleeding disorder, or it may be a secondary...

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