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Arthritis is inflammation of a joint, characterized by swelling, erythema, tenderness, and warmth. A number of etiologies of arthritis are associated with systemic illness that may necessitate hospitalization. These include systemic juvenile idiopathic arthritis (sJIA), acute rheumatic fever (ARF), poststreptococcal arthritis (PSA), reactive arthritis, disseminated gonococcal infection (DGI), and serum sickness (SS) or serum sickness–like reactions (SSLRs). The differential diagnosis for arthritis syndromes appears in Table 56–1.

Acute rheumatic fever is a diffuse inflammatory process triggered by group A...

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