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57: Henoch-Schönlein Purpura (Immunoglobulin a Vasculitis)
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Published:May 2023
Stacy B. Pierson, MD, FAAP, "Henoch-Schönlein Purpura (Immunoglobulin a Vasculitis)", Caring for the Hospitalized Child: A Handbook of Inpatient Pediatrics, American Academy of Pediatrics Section on Hospital Medicine, Jeffrey C. Gershel, MD, FAAP, Daniel A. Rauch, MD, FAAP, SFHM
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Henoch-Schönlein purpura (HSP), now known as immunoglobulin A vasculitis, is a systemic, predominantly immunoglobulin A (IgA)–mediated vasculitis. It is characterized by nonthrombocytopenic palpable purpura and the presence of any 1 of the following 4 criteria: (1) diffuse acute-onset abdominal pain, (2) histopathological findings of typical leukocytoclastic vasculitis with predominant IgA deposits or proliferative glomerulonephritis with predominant IgA deposits, (3) arthritis/arthralgia, and (4) renal manifestations in the form of hematuria or proteinuria. HSP is the most common vasculitis of childhood, with 75% of cases occurring between 2 and 11 years of age and a peak incidence at 5 years of...
