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64: Fever of Unknown Origin
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Published:May 2023
Scott Carney, MD, FAAP, Kuo Chen, MD, "Fever of Unknown Origin", Caring for the Hospitalized Child: A Handbook of Inpatient Pediatrics, American Academy of Pediatrics Section on Hospital Medicine, Jeffrey C. Gershel, MD, FAAP, Daniel A. Rauch, MD, FAAP, SFHM
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Fever of unknown origin (FUO) is defined as a temperature higher than 38.3 °C (101.0 °F) for at least 2 weeks, without a definitive cause, despite a thorough clinical evaluation. There is a vast number of causes of FUO, with infections (especially in a patient < 6 years old) and rheumatologic diseases (in older children) accounting for up to 60% of diagnoses. Fever of unknown origin most often represents a common disease process that presents in an uncommon fashion, such as an occult viral (Epstein-Barr virus [EBV], cytomegalovirus) or bacterial (osteomyelitis, urinary tract infection, missed appendicitis with abdominal abscess) infection....
