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72: Hemolytic Uremic Syndrome
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Published:May 2023
Gabriella C. Azzarone, MD, FAAP, Sheila K. Liewehr, MD, "Hemolytic Uremic Syndrome", Caring for the Hospitalized Child: A Handbook of Inpatient Pediatrics, American Academy of Pediatrics Section on Hospital Medicine, Jeffrey C. Gershel, MD, FAAP, Daniel A. Rauch, MD, FAAP, SFHM
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Hemolytic uremic syndrome (HUS) is a disorder characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal injury. Classically, it follows a prodrome of a diarrheal illness. Most patients will recover completely, but 3% to 5% will progress to renal failure. Most cases occur in children younger than 5 years, often during the summer and fall.
Cases of HUS are classified as either primary (formerly atypical or diarrhea negative) or secondary (formerly typical or diarrhea positive). Approximately 10% of cases of HUS are classified as primary, which include genetic or acquired disorders of regulatory components of the complement...
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