Completely revised and updated, the second edition of this authoritative guide provides the latest information on the diagnosis, treatment, and ongoing management of pulmonary issues in children. Available for purchase at https://www.aap.org/Pediatric-Pulmonology-2nd-Edition-Paperback
9: Allergic Bronchopulmonary Aspergillosis
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Published:November 2023
Richard M. Kravitz, MD, FAAP, "Allergic Bronchopulmonary Aspergillosis", Pediatric Pulmonology, American Academy of Pediatrics Section on Pediatric Pulmonology and Sleep Medicine, Michael J. Light, MD, FAAP, Kristin Van Hook, MD, MPH, FAAP
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Allergic bronchopulmonary aspergillosis (ABPA) is a T-helper 2 (Th2 cell) and immunoglobulin E (IgE)–mediated allergic reaction to the mold Aspergillus fumigatus. This ubiquitous mold is usually of little consequence in the immunocompetent host. In patients with an immunodeficiency, however, this mold can infect the lung, leading to an overwhelming infection. Patients with asthma and cystic fibrosis (CF) can become colonized with this organism, and while no actual infection is present, the body’s immune system mounts a Th2 inflammatory response marked by increased expression of interleukin (IL) 5 (IL-5) and IL-13, leading to eosinophil recruitment to the lung and increased production...
