Completely revised and updated, the second edition of this authoritative guide provides the latest information on the diagnosis, treatment, and ongoing management of pulmonary issues in children. Available for purchase at https://www.aap.org/Pediatric-Pulmonology-2nd-Edition-Paperback
57: Bronchodilators
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Published:November 2023
John Welter, MD, H. William Kelly, PharmD, Leslie Hendeles, PharmD, "Bronchodilators", Pediatric Pulmonology, American Academy of Pediatrics Section on Pediatric Pulmonology and Sleep Medicine, Michael J. Light, MD, FAAP, Kristin Van Hook, MD, MPH, FAAP
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Bronchodilators are used in a number of obstructive respiratory diseases of childhood for the relief of airway smooth muscle contraction (ie, bronchospasm). Although bronchodilators are approved by the US Food & Drug Administration (FDA) only for the treatment of asthma and chronic obstructive pulmonary disease (COPD), they are commonly prescribed for children with cystic fibrosis (CF), bronchiolitis, and bronchopulmonary dysplasia (BPD), despite lack of consistent evidence of efficacy for these conditions.
Neonates are born with fully functional airway smooth muscle whose mass relative to airway size is fully developed by 25 weeks’ gestation.1 Neonatal bronchial tissue responds to both...
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