Source:Lindeboom JA, Kuijper EJ, van Coppenraet B, et al. Surgical excision versus antibiotic treatment for nontuberculous mycobacterial cervicofacial lymphadenitis in children: a multicenter, randomized controlled trial.
Clin Infect Dis.
2007
;
44
:
1057
–1064; doi:10.1086/512675

The optimal treatment for nontuberculous mycobacterial (NTM) cervicofacial lymphadenitis (CFL) has not been established. Investigators from the Netherlands report the results of a randomized trial of antibiotic treatment compared with surgical excision for NTM CFL. Between September 2001 and December 2004, 100 immunocompetent children with more than three weeks of culture- and/or PCR-documented NTM CFL were randomized to either receive clarithromycin and rifabutin or undergo surgical excision. A single oromaxillofacial surgeon performed all the excisions. Those patients randomized to antibiotic treatment received ≥12 weeks of clarithromycin (15 mg/kg in 2 divided doses) and rifabutin (5 mg/kg once daily).

Patients were followed up at 2, 4, 6, 12, and 24 weeks after start of...

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