Source:van Gestel JPJ, Bollen CW, van der Tweel I, et al. Intensive care unit mortality trends in children after hematopoietic stem cell transplantation: a meta-regression analysis.
Crit Care Med.
–2904; doi:10.1097/CCM.0b013e318186a34a

The objective of the current study was to analyze intensive care unit (ICU) mortality trends and the main prognostic factors associated with hospital death in pediatric hematopoietic stem cell transplantation (HSCT, also known as bone marrow transplant) recipients.

Need for ICU care after HSCT has historically been associated with high mortality rates. Whether ICU mortality for HSCT recipients has improved with better support methods is controversial.1,3 

Investigators from the Wilhelmina Children’s Hospital and Utrecht University in the Netherlands performed a comprehensive literature search in articles published through August 2006 on ICU mortality trends following HSCT and factors associated with death. Because of the heterogeneity of reported ICU mortality rates,...

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