Source:Männistö T, Vääräsmäki M, Pouta A, et al. Perinatal outcome of children born to mothers with thyroid dysfunction or antibodies: a prospective population-based cohort study.
J Clin Endocrinol Metab.
–779; doi:10.1210/jc.2008-1520

Investigators from Finland and the UK prospectively evaluated the effect of maternal thyroid dysfunction and autoimmunity on perinatal outcomes. Data on 9,247 pregnant Finnish women and their singleton births from the Northern Finland Birth Cohort were analyzed. Blood samples from a subset of mothers during the first trimester were analyzed for serum free T4 (fT4), thyroid stimulating hormone (TSH), thyroid-peroxidase antibody (TPO-Ab), and thyroglobulin antibody (TG-Ab). The study participants were divided into four groups based on thyroid studies: 1) clinical hypothyroidism (high TSH, low fT4); 2) subclinical hypothyroidism (high TSH, normal fT4); 3) subclinical hyperthyroidism (low TSH, normal fT4); and 4) clinical hyperthyroidism (low TSH, high fT4).

Blood samples were available from 5,805...

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