Source:Tobian AR, Serwadda D, Quinn TC, et al. Male circumcision for the prevention of HSV-2 and HPV infection and syphilis.
N Engl J Med.
2009
;
360
(13):
1298
–1309; doi:10.1056/ NEJMoa0802556

This collaboration of authors from the Johns Hopkins University, the National Institutes of Health, the Makerere University in Kampala, and the Rakai Health Sciences Program in Entebbe, Uganda sought to determine if male circumcision significantly reduced the incidence of herpes simplex virus type 2 (HSV-2), human papillomavirus (HPV) infections, and syphilis in HIV-negative adolescent boys and men between the ages of 15 and 49 years.

A total of 5,534 adolescent boys and men were enrolled in two studies of male circumcision. Of these, 3,393 (61.3%) were HSV-2 seronegative. Of these HSV-2 seronegative participants, 1,684 were randomly assigned to immediately undergo circumcision (intervention group) and 1,709 were assigned to undergo circumcision after 24 months (control group). Participants were...

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