Source:

Webb
NJA
,
Woolley
RL
,
Lambe
T
, et al
.
Long term tapering versus standard prednisolone treatment for first episode of childhood nephrotic syndrome: phase III randomised controlled trial and economic evaluation
.
BMJ
.
2019
;
365
:
l1800
; doi:
https://doi.org/10.1136/bmj.l1800

Investigators from multiple institutions in the United Kingdom conducted a randomized controlled trial to compare the effectiveness of a prolonged tapering regimen of prednisolone to the standard regimen in childhood nephrotic syndrome. Study participants were children 1–14 years old with their first episode of steroid-sensitive nephrotic syndrome. Eligibility requirements included a ratio of first morning urine protein (or albumin) to creatinine >200 mg/mmol, serum or plasma albumin level <25 g/L, and no previous treatment with corticosteroids. All study patients were treated with prednisolone 60 mg/m2 daily for 4 weeks at which point they were randomized to complete a course of prednisolone,...

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