Source:

TODAY Study Group
,
Bjornstad
P
,
Drews
KL
,
Caprio
S
, et al
.
Long-term complications in youth-onset type 2 diabetes
.
N Engl J Med
.
2021
;
385
(
5
):
416
426
; doi:
10.1056/NEJMoa2100165

Investigators from multiple institutions conducted a prospective longitudinal study to assess the rate of complications among individuals with youth-onset type 2 diabetes. Participants originally were enrolled in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study, in which children 10–17 years of age with type 2 diabetes were randomized to receive metformin alone, metformin plus rosiglitazone, or metformin plus intensive lifestyle changes. Study children were enrolled from 2004 to 2009 and followed for an average of 3.9 years. In 2011, these participants were enrolled in TODAY2, managed with metformin with or without insulin, and followed until 2014. Beginning in 2014, participants...

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