Source:

Halmo
LS
,
Wang
GS
,
Reynolds
KM
, et al
.
Pediatric fatalities associated with over-the-counter cough and cold medications [published online ahead of print October 4, 2021]
.
Pediatrics
.
2021
:
e2020049536
; doi.
https://doi.org/10.1542/peds.2020-049536

Investigators from multiple institutions conducted a study to describe fatalities due to ingestion of cough and cold medications (CCMs) in children following a 2008 FDA recommendation to not use these products in children <2 years old and a labelling change by drug manufacturers to not use in children <4 years old. Cases were identified by the Pediatric Cough and Cold Safety Surveillance System that collected data on ingestions from multiple sources, including poison control centers, FDA reporting systems, and media reports. Cases were children <12 years old who died after oral exposure to 1 or more of 8 index ingredients (brompheniramine, chlorpheniramine, dextromethorphan, diphenhydramine, doxylamine, guaifenesin, phenylephrine, or pseudoephedrine)...

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