Source:Ciarallo L, Brousseau D, Reinert S. Higher-dose intravenous magnesium therapy for children with moderate to severe acute asthma.
Arch Pediatr Adolesc Med.
2000
;
154
:
979
–983.

In a double-blind study, 30 children at Rhode Island Hospital with moderate to severe acute asthma exacerbations and peak expiratory flow rates (PEFR) < 70% predicted after 3 treatments with nebulized albuterol or ipratropium bromide (or both) were randomized to receive either 40 mg/kg (maximum dose 2 gm) of magnesium sulfate intravenously over 20 minutes (16 patients, 11 male, mean age 10.9 years) or normal saline (14 patients, 7 male, mean age 12 years). The children were given intravenous steroids if they had not already received steroids when the IV catheter was placed. Additional nebulized treatments were given at the discretion of the provider. Peak expiratory flow rate (PEFR), forced expiratory volume in 1 sec (FEV1), forced vital capacity...

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