Twenty-one children (17 boys) with 21ß-hydroxylase adrenal enzyme deficiency and 5 children (4 boys) with 11-hydroxylase enzyme deficiency were consecutively treated with dexamethasone instead of the more commonly used hydrocortisone and followed for an average of 7 years at 2 New England referral centers (Yale and Massachusetts General Hospital). Salt-losing patients were also treated with standard florinef doses. These 26 patients with congenital adrenal hyperplasia (CAH) were started on a daily morning dose of 0.25 to 0.28 mg/m2/day of dexamethasone administered as an elixir (0.1 mg/mL). The patients were evaluated every 3 to 4 months and the dose adjusted to maintain normal growth rate and normal adrenal androgen secretion for age. Most patients were maintained on a dose of 0.24 to 0.33...
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Endocrinology| January 01 2001
Dexamethasone Instead of Hydrocortisone for CAH
AAP Grand Rounds (2001) 5 (1): 5–6.
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Dexamethasone Instead of Hydrocortisone for CAH. AAP Grand Rounds January 2001; 5 (1): 5–6. https://doi.org/10.1542/gr.5-1-5
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