The Centers for Disease Control and Prevention (CDC) is soliciting reports from pediatricians about possible cases of influenza-associated encephalopathy in American children.

Since the mid-1990s, several hundred such cases have been reported in Japanese children, according to the CDC. These cases have been characterized by fever and rapid onset of encephalopathy and resulted in a high frequency of neurological sequelae and mortality. Most of the children had laboratory-confirmed evidence of influenza.

To determine whether this clinical entity is occurring among U.S. children, the CDC is requesting details on cases in individuals younger than 18 years old with all of the following criteria:

Report cases to Tim Uyeki, M.D., M.P.H., M.P.P., FAAP, at (404) 639-0277 or; or Jim Sejvar, M.D., at (404) 639-4657 or The information will be used to determine if additional investigation is warranted.

You do not currently have access to this content.