Hall
C
, et al
                
N Engl J Med
                
2009
;
360
:
588
-598
.

Respiratory syncytial virus (RSV) infection is far more widespread among children under 5 years of age than previously recognized, according to a prospective, population-based surveillance of acute respiratory infections among children in three U.S. counties.

Studies have identified the primary role of RSV in causing hospitalizations in infants, but little is known about the total burden of RSV infection during the first five years of life.

The Centers for Disease Control and Prevention initiated the New Vaccine Surveillance Network in 2000 in Nashville, Tenn., and Rochester, N.Y., and in 2003 in Cincinnati. Inpatient surveillance was conducted from 2000-’04, while outpatient surveillance was conducted from 2002-’04.

Photomicrographic detection of respiratory syncytial virus (RSV) using indirect immunofluorescence technique.

Researchers interviewed parents or guardians to obtain demographic, medical and social histories. Laboratory and clinical information was...

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