Pediatricians will see changes in the concentration and dosing label for oral oseltamivir phosphate (Tamiflu; manufacturer: Genentech), but should watch for both old and new concentrations of the drug during the approaching influenza season.

The change in concentration of oseltamivir from 12 mg/mL to 6 mg/ mL has been made to improve accuracy in measurement due to the medication’s tendency to become frothy when shaken, according to the Food and Drug Administration (FDA). The dosing label also is updated to include a column for volume in milliliters based on the new 6 mg/mL concentration; the measuring device used with the medication will reflect milliliters.

FDA is advising health care clinicians to include the 6 mg/mL concentration and dose in milliliters on all prescriptions for oral Tamiflu suspension.

Some 12 mg/mL oseltamivir will remain in the marketplace and in state and national stockpiles until supplies expire, but Genentech has instituted a...

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