While e-prescribing offers many benefits for children and adults, some of the unique needs of young infants have not been addressed, compromising the safety of pediatric prescribing.

For example, typical e-prescribing systems that calculate doses rely on medication knowledge bases that provide weight-based dosing recommendations. Before that dose can be prescribed, however, it generally is rounded to the nearest measurable and easily administered amount. Currently, the prescriber performs this step manually, which can lead to over- or underdosing, based on the medication’s properties.

Another challenge is that extemporaneous formulations (compounded or diluted formulations) generally are not characterized in drug knowledge bases, even though many of the active ingredients are potentially toxic.

Without these data, e-prescribing in pediatrics will continue to have a knowledge gap that will affect both safety and adoption. For this gap to be solved in the short term, developers need knowledge created by and endorsed by pediatricians,...

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