Cellular transplantation offers the potential to treat many human neurological diseases. The first, and so far only, trials investigating stem cell transplantation directly into the brain have been conducted in two rare and fatal pediatric disorders.

Cell therapy refers to a broad regenerative approach in which transplantation of donor cells is performed to replace and/or repair host cells affected by disease. Neural stem cells are considered one of the leading candidates for such an approach, and several neurological disorders are appropriate targets for clinical testing (

, et al
J Clin Invest

Neural stem cells (NSC) are capable of self-renewal and differentiation into neurons, oligodendrocytes and astrocytes — the three cellular building blocks of the central nervous system (CNS). Tissue-derived human NSC when placed into animal models demonstrate the ability to engraft, migrate and differentiate into CNS cell types, all properties...

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