The relationship between vaccines and seizures has been influenced not only by the medical literature but also by legislative actions and legal proceedings.

Given the amount of information available, some vaccine providers may be unclear as to when they should defer vaccines to prevent seizures in certain patients as well as the contraindications for vaccination.

Following are some guidelines based on the medical evidence available to date.

Seizures as a potential complication of vaccination were first described in isolated case reports about early diphtheria, tetanus and pertussis (DTP) vaccines and, more recently, in population and case-control studies. Studies have shown an increased risk of seizures associated with fever, but not epilepsy, within a few days of DTP vaccination.

Fewer children have seizures within a few days of receiving diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccine compared to DTP vaccine (one per 15,000 or fewer children who receive DTaP...

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