Did you know that up to 12 percent of patients with infantile hypothyroidism will have normal neonatal screening test results regardless of the method used?

Why? U.S. screening programs currently use a two-tiered laboratory approach — an initial T4, followed by TSH if T4 levels are low or low-normal. This combination detects infants with primary hypothyroidism (1:3,500 to 4,500 newborns) as well as those with Thyroxine-binding globulin deficiency and even hypothalamic-pituitary hypothyroidism (1:50,000 to 150,000 newborns respectively).

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