Antigenic constituents of human milk or of alternative feedings for infants may be responsible for adverse reactions in a subset of infants with milk-protein intolerance. These reactions include those commonly associated with atopy, such as angioedema, urticaria, wheezing, vomiting and eczema.1 Pulmonary hemosiderosis,2 malabsorption with villous atrophy,3 and eosinophilic enterocolitis,4 perhaps mediated by immune complexes or T cells, have also been associated with the ingestion of cow milk proteins and/or soy proteins in infant feedings.

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