In a recent Second Opinion (AAP News, August 1991), Dr. Laura Barker expressed justifiable concerns regarding breast-feeding and HIV-positive mothers. Most transmission of AIDS from mother to child occurs in utero or during delivery. Human immunodeficiency virus has been isolated from breast milk. Several cases of infants acquiring HIV from mothers who first become infected from blood transfusions during delivery and then breast-fed have been reported. However, many of these reports were retrospective, did not absolutely rule out other routes of infection and testing for HIV in the mother's milk was not performed in any of these cases (Belec L, et al. Antibodies to human immunodeficiency virus in the breast milk of healthy, seropositive women. Pediatrics. 1990;85:1022-1026).