Chemotherapeutic agents used to treat children and adolescents with cancer have not been found to increase the prevalence of congenital abnormalities in the children of these former patients, according to a study published in the July 18 New England Journal of Medicine.

Researchers studied the records of 306 men and women who had been treated for pediatric cancer. Many of the chemotherapeutic agents used were mutagenic, which could potentially injure germ-cell chromosomes.

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