In 2021, the American Academy of Pediatrics published a clinical practice guideline (CPG) for the management of well-appearing febrile infants 8 to 60 days old. This CPG is based on decades of research to identify the optimal approach to risk-stratify febrile infants on the basis of their risk of a serious bacterial infection (SBI), particularly bacteremia and bacterial meningitis (invasive bacterial infections [IBI]). Despite a nonnegligible risk of SBI of ∼2% to 3%, there is no corresponding CPG to guide the management of infants with hypothermia, resulting in wide variability in diagnosis, evaluation, and management.

In this issue of Hospital Pediatrics, 2 studies build on the limited evidence for risk stratification of young infants with hypothermia with 2 different approaches. In a 4-site case-control study of 171 infants with temperatures <36.5°C and blood cultures obtained, Money et al identified several risk factors for SBI, including age, fever,...

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