OBJECTIVE

Communication skills are critical to pediatric practice, but few pediatric residency programs provide formal communication skills education. Pediatric residents often lack confidence in these skills. We hypothesized that a simulation-based communication skills course would improve resident confidence in the skills required for serious illness conversations with patients/families.

METHODS

In collaboration with multidiscipline VitalTalk-trained faculty, we developed PedsTalk, a communication skills course for pediatric residents based on the VitalTalk framework. In PedsTalk, faculty/peers offered real-time coaching during simulation sessions with actors. Resident participants self-rated confidence in 9 communication skills using a 5-point Likert scale before, immediately after, and 4 months after course participation, with course nonparticipants serving as controls. Responses were analyzed by using Friedman tests and Wilcoxon rank tests. Thematic analysis was conducted to identify themes among free-text responses.

RESULTS

Twenty-seven pediatric residents participated in PedsTalk, 11 of whom completed survey assessments at all timepoints. Eleven course nonparticipants served as controls. Over time, participants’ confidence in the following communication skills was retained or significantly improved: “difficult conversations” (P < .001), “recognizing emotion” (P < .01), “using silence” (P < .008), “headline statements” (P < .001), eliciting “VALUES” (P < .001), and asking “permission to continue” (P < .001). Over time, controls had significant improvements in confidence in 2 skills: headline statements (P < .014) and eliciting “VALUES” (P < .031).

CONCLUSIONS

PedsTalk is a novel approach to communication skills education in pediatric residency. Participation improved residents’ confidence in 6 communication skills, including overall confidence in having difficult conversations. Although confidence in some skills may naturally develop through clinical experiences, PedsTalk further enhances communication skills education among trainees.

High-quality physician-family communication results in improved health outcomes and greater satisfaction among patients/families.14  Enhanced communication also benefits clinicians by improving empathy and mitigating burnout.5  Pediatricians confront unique communication challenges, such as navigating social dynamics with young patients and parents and managing emotions that arise with the delivery of difficult news.1,2,6  Given the importance of communication skills and challenges encountered, it is vital that pediatricians receive communication skills education.

Despite the Accreditation Council for Graduate Medical Education Pediatric Milestones’ emphasis on patient/family-centered communication as a core competency, few pediatric residency programs provide formal communication skills education.3,713  Pediatric residents report lacking confidence in communication skills, further reinforcing the need for robust skills education during training.3,6,7 

VitalTalk is the gold standard among serious illness communication training.1,1417  VitalTalk employs an evidence-based framework for conversations relating to serious illness.1,10,14,17  Given the need for communication education in pediatrics and the benefits of the VitalTalk approach, there has been interest in the application of VitalTalk within pediatrics.6,13,15,16 

There is limited literature on the use of the VitalTalk framework to teach communication skills to pediatric residents. Our study was aimed to understand pediatric residents’ experiences with communication skills and examine the impact of a VitalTalk-based communication skills course on pediatric residents. We hypothesized that a simulation-based communication skills course would improve resident confidence in the skills required for serious illness conversations with patients/families.

PedsTalk was created in collaboration with VitalTalk-trained adult medicine faculty at our institution using content adapted from a pediatrics-focused VitalTalk course at the Larner College of Medicine at the University of Vermont.1,15,16  Our 3-hour course, conducted on a virtual platform because of coronavirus disease 2019 restrictions, focused on key communication skills, including communicating serious news, responding to emotion, eliciting patient/family values, and making values-based treatment recommendations. PedsTalk included an asynchronous online module and simulation-based roleplay with trained actors. Components of PedsTalk are discussed further in our previous work and online VitalTalk material.1,17  Small groups were facilitated by VitalTalk-trained faculty paired with pediatric faculty “Communication Champions,” who had received communication skills training.1 

Course participants were residents across postgraduate years present at the program’s weekly academic conference, with attendance based on a predetermined rotation schedule. Participants completed demographic surveys and rated confidence with 9 communication skills using a 5-point Likert scale before, immediately after, and 4 months after course participation. Nonparticipants, residents unable to attend because of inpatient responsibilities, completed surveys and acted as controls. Survey questions mirrored the VitalTalk framework and were designed to assess study aims (understanding resident communication experiences and examining communication skill confidence). For example, to determine confidence in skills, respondents identified their level of agreement/disagreement with the statement: “I am confident in my ability to recognize emotion in patients/families.” Responses were analyzed by using Friedman tests and Wilcoxon rank tests. Respondents provided free-text responses to questions about communication experiences with pediatric patients/families. Before PedsTalk, residents were asked about communication challenges in pediatrics. Immediately after the course, individuals were queried about takeaway lessons, and at 4 months follow-up, they were asked to reflect on recent communication experiences. By using Braun and Clarke’s approach, a thematic analysis was performed to analyze free-text responses.18  Three authors (CC, KG, SK) reviewed responses for initial themes which were revised to reach concordance.

This project was designated as exempt human subjects research by the Institutional Review Board at the Icahn School of Medicine at Mount Sinai.

Twenty-seven residents (approximately one-third of our pediatric residency program) took the PedsTalk course, 11 of whom completed surveys at all 3 timepoints. Eleven course nonparticipants completed surveys at all timepoints and served as controls. Both participants and controls were lost to follow-up. Most participants identified as White and female and were 26 to 30 years old (Table 1). Most participants received <5 hours of formal communication education during residency, with “observing senior team members” cited as the most common method of communication education. All endorsed the need for communication skills training during residency.

TABLE 1

Characteristics of the Study Population (N = 22)

Personal and Professional CharacteristicsIntervention, n/N (%)Control, n/N (%)Total, n/N (%)
Age, 26–30 y 8/10 (80%) 7/10 (70%) 15/20 (75%) 
Female sex 7/9 (78%) 7/9 (78%) 14/18 (78%) 
Race/ethnicity    
 White 5/9 (56%) 7/10 (70%) 12/19 (63%) 
 Black/African American 2/9 (22%) 0/10 (0%) 2/19 (11%) 
 Latinx 0/9 (0%) 2/10 (20%) 2/19 (11%) 
Postgraduate year    
 PGY-1 3/11 (27%) 4/11 (36%) 7/22 (32%) 
 PGY-2 4/11 (36%) 5/11 (45%) 9/22 (41%) 
 PGY-3 4/11 (36%) 2/11 (18%) 6/22 (27%) 
Career plans    
 General pediatrics 4/11 (36%) 4/11 (36%) 8/22 (36%) 
 Subspecialty/fellowship 2/11 (18%) 4/11 (36%) 6/22 (27%) 
 Undecided 4/11 (36%) 2/11 (18%) 6/22 (27%) 
Medical school communication education    
 Total time spent >5 h, formal educational content 8/10 (80%) 10/11 (91%) 18/21 (86%) 
Method of communication education    
 Watching senior team members having challenging discussions 11/11 (100%) 11/11 (100%) 22/22 (100%) 
 Having senior team members watch you lead challenging discussions 2/11 (18%) 5/11 (45%) 7/22 (32%) 
 Lecture-based 8/11 (73%) 10/11 (91%) 18/22 (82%) 
 Online education including webinars or videos 4/11 (36%) 4/11 (36%) 8/22 (36%) 
 Workshops/skills sessions; role-playing or simulation based 11/11 (100%) 10/11 (91%) 21/22 (95%) 
Focus of communication education    
 Breaking difficult news 11/11 (100%) 11/11 (100%) 22/22 (100%) 
 Goals of care conversations 7/11 (64%) 6/11 (55%) 13/22 (59%) 
 End-of-life conversations 6/11 (55%) 7/11 (64%) 13/22 (59%) 
 Discussions of medical errors 5/11 (45%) 7/11 (64%) 12/22 (55%) 
Residency communication education    
 Total time spent ≤5 h, formal educational content 10/11 (91%) 9/10 (90%) 19/21 (90%) 
Method of communication education    
 Watching senior team members having challenging discussions 9/11 (82%) 10/11 (91%) 19/22 (86%) 
 Having senior team members watch you lead challenging discussions 5/11 (45%) 7/11 (64%) 12/22 (55%) 
 Lecture-based 5/11 (45%) 3/11 (27%) 8/22 (36%) 
 Online education including webinars or videos 0/11 (0%) 2/11 (18%) 2/22 (9%) 
 Workshops/skills sessions; role-playing or simulation based 1/11 (9%) 2/11 (18%) 3/22 (14%) 
Focus of communication education    
 Breaking difficult news 7/11 (64%) 7/11 (64%) 14/22 (64%) 
 Goals of care conversations 8/11 (73%) 7/11 (64%) 15/22 (68%) 
 End-of-life conversations 4/11 (36%) 2/11 (18%) 6/22 (27%) 
 Discussions of medical errors 6/11 (55%) 4/11 (36%) 10/22 (45%) 
Number of difficult conversations involved in during residency    
 0 2/11 (18%) 1/11 (9%) 3/22 (14%) 
 1–5 8/11 (73%) 6/11 (55%) 14/22 (64%) 
Endorsed need for communications skills education in pediatric residency 11/11 (100%) 11/11 (100%) 22/22 (100%) 
Personal and Professional CharacteristicsIntervention, n/N (%)Control, n/N (%)Total, n/N (%)
Age, 26–30 y 8/10 (80%) 7/10 (70%) 15/20 (75%) 
Female sex 7/9 (78%) 7/9 (78%) 14/18 (78%) 
Race/ethnicity    
 White 5/9 (56%) 7/10 (70%) 12/19 (63%) 
 Black/African American 2/9 (22%) 0/10 (0%) 2/19 (11%) 
 Latinx 0/9 (0%) 2/10 (20%) 2/19 (11%) 
Postgraduate year    
 PGY-1 3/11 (27%) 4/11 (36%) 7/22 (32%) 
 PGY-2 4/11 (36%) 5/11 (45%) 9/22 (41%) 
 PGY-3 4/11 (36%) 2/11 (18%) 6/22 (27%) 
Career plans    
 General pediatrics 4/11 (36%) 4/11 (36%) 8/22 (36%) 
 Subspecialty/fellowship 2/11 (18%) 4/11 (36%) 6/22 (27%) 
 Undecided 4/11 (36%) 2/11 (18%) 6/22 (27%) 
Medical school communication education    
 Total time spent >5 h, formal educational content 8/10 (80%) 10/11 (91%) 18/21 (86%) 
Method of communication education    
 Watching senior team members having challenging discussions 11/11 (100%) 11/11 (100%) 22/22 (100%) 
 Having senior team members watch you lead challenging discussions 2/11 (18%) 5/11 (45%) 7/22 (32%) 
 Lecture-based 8/11 (73%) 10/11 (91%) 18/22 (82%) 
 Online education including webinars or videos 4/11 (36%) 4/11 (36%) 8/22 (36%) 
 Workshops/skills sessions; role-playing or simulation based 11/11 (100%) 10/11 (91%) 21/22 (95%) 
Focus of communication education    
 Breaking difficult news 11/11 (100%) 11/11 (100%) 22/22 (100%) 
 Goals of care conversations 7/11 (64%) 6/11 (55%) 13/22 (59%) 
 End-of-life conversations 6/11 (55%) 7/11 (64%) 13/22 (59%) 
 Discussions of medical errors 5/11 (45%) 7/11 (64%) 12/22 (55%) 
Residency communication education    
 Total time spent ≤5 h, formal educational content 10/11 (91%) 9/10 (90%) 19/21 (90%) 
Method of communication education    
 Watching senior team members having challenging discussions 9/11 (82%) 10/11 (91%) 19/22 (86%) 
 Having senior team members watch you lead challenging discussions 5/11 (45%) 7/11 (64%) 12/22 (55%) 
 Lecture-based 5/11 (45%) 3/11 (27%) 8/22 (36%) 
 Online education including webinars or videos 0/11 (0%) 2/11 (18%) 2/22 (9%) 
 Workshops/skills sessions; role-playing or simulation based 1/11 (9%) 2/11 (18%) 3/22 (14%) 
Focus of communication education    
 Breaking difficult news 7/11 (64%) 7/11 (64%) 14/22 (64%) 
 Goals of care conversations 8/11 (73%) 7/11 (64%) 15/22 (68%) 
 End-of-life conversations 4/11 (36%) 2/11 (18%) 6/22 (27%) 
 Discussions of medical errors 6/11 (55%) 4/11 (36%) 10/22 (45%) 
Number of difficult conversations involved in during residency    
 0 2/11 (18%) 1/11 (9%) 3/22 (14%) 
 1–5 8/11 (73%) 6/11 (55%) 14/22 (64%) 
Endorsed need for communications skills education in pediatric residency 11/11 (100%) 11/11 (100%) 22/22 (100%) 

Survey prompts were optional, and thus, not all responders answered every question.

Participants’ confidence in the following communication skills was retained or significantly improved over time: difficult conversations (P < .001), recognizing emotion (P < .01), using silence (P < .008), headline statements (P < .001), eliciting “VALUES”, (P < .001), and asking permission to continue (P < .001; Table 2). Over time, controls had significant improvements in confidence in 2 skills: headline statements (P < .014) and eliciting “VALUES” (P < .031; Supplemental Table 4).

TABLE 2

Perceived Confidence in Communication Skills for Course Participants Over Time

Communication SkillMedian Scores Over Time (Time 1/Time 2/Time 3)Mean Ranks Over Time (Time 1/Time 2/Time 3)χ2P
Overall ability to have difficult conversations 3/4/4 1.18/2.5/2.32 17.03 <.001* 
Recognizing emotion in patients/families 4/4/5 1.55/1.95/2.5 9.25 .01* 
Responding to emotion with “NURSE” statement 4/4/4 1.64/2.23/2.14 6.12 .05 
Illness understanding 4/4/4 1.68/2.09/2.23 5.2 .07 
Using silence in conversation 4/5/4 1.59/2.45/1.95 9.58 .008* 
Employing headline statements when sharing news 2/4/4 1.23/2.59/2.18 15.8 <.001* 
Determining what is most important 4/4/4 1.95/2.27/1.77 2.82 .24 
Using “VALUES” questions to elicit goals/values 1/4/2 1.23/2.82/1.95 17.54 <.001* 
Asking permission to continue the conversation 3/4/4 1.18/2.59/2.23 16.7 <.001* 
Communication SkillMedian Scores Over Time (Time 1/Time 2/Time 3)Mean Ranks Over Time (Time 1/Time 2/Time 3)χ2P
Overall ability to have difficult conversations 3/4/4 1.18/2.5/2.32 17.03 <.001* 
Recognizing emotion in patients/families 4/4/5 1.55/1.95/2.5 9.25 .01* 
Responding to emotion with “NURSE” statement 4/4/4 1.64/2.23/2.14 6.12 .05 
Illness understanding 4/4/4 1.68/2.09/2.23 5.2 .07 
Using silence in conversation 4/5/4 1.59/2.45/1.95 9.58 .008* 
Employing headline statements when sharing news 2/4/4 1.23/2.59/2.18 15.8 <.001* 
Determining what is most important 4/4/4 1.95/2.27/1.77 2.82 .24 
Using “VALUES” questions to elicit goals/values 1/4/2 1.23/2.82/1.95 17.54 <.001* 
Asking permission to continue the conversation 3/4/4 1.18/2.59/2.23 16.7 <.001* 

NURSE, Naming, Understanding, Respecting, Supporting, Exploring; VALUES, Vital goals, Activities, Limits, Uncertainties, Experience with illness, Strength.

Resident participants’ perceived confidence in skills were assessed using a 5-point Likert scale with responses ranging from strongly disagree (1) to strongly agree (5) for skills taught in the PedsTalk program.

Time 1, before course; Time 2, after course; Time 3, 4 months post-course.

*

Denotes significance (P < .05).

When queied about communication challenges in pediatrics, 3 themes were identified: pediatric patient, parent/guardian, and pediatric provider (Table 3). Within each of these areas, the following subthemes emerged: understanding the situation, emotional response, advocate, and practice uncertainty. For example, acknowledging the emotional challenge of communicating bad news to parents, one respondent wrote: “It’s heartbreaking to have to share this news and I think it’s difficult to keep my own emotion out of the conversation.” After the course, participants reported learning and practicing numerous new communication skills, such as “Ask-Tell-Ask” and responding to emotion, with one respondent setting a goal to “develop a more concrete headline before speaking with famil[ies].” Lastly, at 4 months follow-up, respondents reflected on recent communication experiences and reported using communication skills in their clinical practice, including: “NURSE statements like Understanding”, “ask-tell-ask to clarify bad news”, and allowing for silence.

TABLE 3

Thematic Analysis: Communication Challenges, Takeaway Lessons, and Clinical Practice Changes

Communication ChallengesFree-Text Response Excerpt
Pediatric patient  
 Understanding the situation What… the patient [should] know depend[s] on age. 
Deciphering how much should be understood by just the parent versus how much the child should understand. 
 Advocate Children’s inability to advocate for themselves when [they are] nonverbal or minors. 
Parent/guardian  
 Understanding the situation Everyone has different levels of education/literacy, which affects their understanding significantly. 
Language barriers. 
 Emotional response Having a sick child is nearly impossible for any parent… and their worst nightmare. 
Pediatric provider  
 Emotional response It’s heartbreaking to have to share [bad] news and I think it’s difficult to keep my own emotion out of the conversation. 
I believe trainees and faculty are often hold back information or prognosis due to their own discomfort rather than viewing it as something that needs to be heard [by the patient/family]. 
 Practice uncertainty Not always having all of the answers. 
Limited experience with having [challenging] discussions. 
Takeaway Lessons  
 REMAP framework Implement the REMAP framework [to guide conversations]. 
I will be trying to keep… REMAP as [a] reference before going into hard conversations. 
 Taught communication skills I will definitely use ‘Ask-Tell-Ask’ … when sharing information with a family, [and] try to develop a more concrete headline before speaking with the family to effectively share vital information. 
 “responding to emotion”, “ask-tell-ask”, “headline statements”, “permission to continue” I will ask families [for permission] to talk about next steps. I will also slow down and address emotions more. I’ll also have more confidence in the words I choose. 
Clinical Practice Changes  
 Applying learned communication skills Patient was [in distress and] … I used NURSE statements like Understanding [to comfort mom]. 
 “recognizing emotion”, “responding to emotion”, “ask-tell-ask”, “headline statements”, “using silence” I have named emotion more … and recently asked for understanding much more than I used to which has been extremely helpful. 
 Using the new techniques learned in … the session, I was able to mediate the situation… One technique that was really powerful was affirming [the parents’] roles as advocate for their child and prais ing [their emotions] … which helped to show I was … aligned with their goals. 
 I used headline statement and ask tell ask to clarify bad news with a family. 
 I allowed for silence which gave family time to process [and] started with [a] headline statement. 
Communication ChallengesFree-Text Response Excerpt
Pediatric patient  
 Understanding the situation What… the patient [should] know depend[s] on age. 
Deciphering how much should be understood by just the parent versus how much the child should understand. 
 Advocate Children’s inability to advocate for themselves when [they are] nonverbal or minors. 
Parent/guardian  
 Understanding the situation Everyone has different levels of education/literacy, which affects their understanding significantly. 
Language barriers. 
 Emotional response Having a sick child is nearly impossible for any parent… and their worst nightmare. 
Pediatric provider  
 Emotional response It’s heartbreaking to have to share [bad] news and I think it’s difficult to keep my own emotion out of the conversation. 
I believe trainees and faculty are often hold back information or prognosis due to their own discomfort rather than viewing it as something that needs to be heard [by the patient/family]. 
 Practice uncertainty Not always having all of the answers. 
Limited experience with having [challenging] discussions. 
Takeaway Lessons  
 REMAP framework Implement the REMAP framework [to guide conversations]. 
I will be trying to keep… REMAP as [a] reference before going into hard conversations. 
 Taught communication skills I will definitely use ‘Ask-Tell-Ask’ … when sharing information with a family, [and] try to develop a more concrete headline before speaking with the family to effectively share vital information. 
 “responding to emotion”, “ask-tell-ask”, “headline statements”, “permission to continue” I will ask families [for permission] to talk about next steps. I will also slow down and address emotions more. I’ll also have more confidence in the words I choose. 
Clinical Practice Changes  
 Applying learned communication skills Patient was [in distress and] … I used NURSE statements like Understanding [to comfort mom]. 
 “recognizing emotion”, “responding to emotion”, “ask-tell-ask”, “headline statements”, “using silence” I have named emotion more … and recently asked for understanding much more than I used to which has been extremely helpful. 
 Using the new techniques learned in … the session, I was able to mediate the situation… One technique that was really powerful was affirming [the parents’] roles as advocate for their child and prais ing [their emotions] … which helped to show I was … aligned with their goals. 
 I used headline statement and ask tell ask to clarify bad news with a family. 
 I allowed for silence which gave family time to process [and] started with [a] headline statement. 

Participation in PedsTalk positively impacted resident confidence in 6 of 9 key communication skills. This is congruent with previous work revealing that dedicated simulation-based communication education positively impacts trainee communication skills, such as responding to emotion and eliciting patient/family values.10,19,20  Novel to our study is the application of the VitalTalk framework to pediatric resident education. VitalTalk offers residents a safe space to practice communication skills in a group setting with faculty coaching and peer feedback. Through these constructive discussions and the ability to “replay” parts of conversations with actors for additional practice, participants may gain more experience using communication skills and augment their confidence.

Although participation in PedsTalk was associated with increased confidence in 6 skills, pediatric residents who did not participate also reported increased confidence in 2 skills (forming headline statements and eliciting values). Because our survey did not query why nonparticipants felt more confident with these skills over time, this warrants further exploration. It has been shown that trainees observe experienced clinicians to inform their own practice as physicians, especially with respect to communication skills.1,2,6  Informal exposure to senior pediatricians communicating serious news to patients/families may be an effective form of communication skills education. However, this relies on the senior provider demonstrating effective communication skills. The creation of pediatric Communication Champions is an example of an initiative to improve communication skills among faculty to model skills and educate trainees, which may be useful given scheduling constraints that make large-scale trainings, such as PedsTalk, difficult.1  Such continuous modeling may allow for better resident skill retention. Residents who completed PedsTalk may also model communication skills and this may represent another form of informal teaching.

Given the variety of communication challenges reported, it is not surprising that respondents endorsed a need for communication skills education in our initial survey. Challenges, such as difficulty responding to emotion, are frequently encountered in serious illness conversations and may be addressed by using the communication skills taught in PedsTalk. Reported PedsTalk takeaway lessons reflected the communication skills taught in the course, indicating concrete skills learned by participants. At 4 months post-PedsTalk, when asked about a recent communication experience, respondents reported using many of the skills learned in the course, demonstrating its longitudinal impact and relevance to clinical practice.

There are several limitations to our study. As a single-center study with a small sample size, the generalizability of our findings is uncertain. Our primary study outcome, the self-assessment of communication skill confidence, carries inherent limitations as self-reported confidence does not necessarily reflect one’s effectiveness in conversations with patients/families.21  Exploring the impact of PedsTalk on resident communication with patients/families warrants study. Resident confidence with serious illness communication may differ with actors versus real patients and may not be the best measure of intervention impact as, for example, residents may report increased confidence due to a belief that they should gain competence over time. There is no standard timeframe for assessing the maintenance of communication skills.10,12,22,23  Further work should be done to establish maintenance of skills after 4 months. Although communication jargon was defined before survey administration, it is possible that respondents did not understand specific terms, such as headline, which may impact results. Additionally, the majority of mean ranks decreased between the immediate post-course survey and 4 months post-course. Our methods do not enable us to explore why this may be and warrants further study. It is possible that individuals who completed our survey were more positively impacted by PedsTalk compared with those who did not complete the survey, or alternatively, the reverse may be true.

Participation in PedsTalk was associated with improved confidence in several key serious illness communication skills among pediatric residents. Although communication skills training and routine clinical experiences may separately augment confidence in communication skills, combining these modalities may further enhance confidence in these skills among trainees. Given its positive impact, our approach to communication skills education may be a model for enhancing communication competencies among pediatric residents.

The authors wish to acknowledge the Department of Pediatrics at the Icahn School of Medicine at Mount Sinai for grant support through the Pediatric Scholars Awards Program.

Dr Kase conceptualized and designed the study, recruited participants, led data collection, analysis, and interpretation, and drafted the initial manuscript; Dr Christianson conceptualized and designed the study,recruited participants, led data collection, analysis, and interpretation, and assisted with the initial manuscript; Dr Dow supervised the conceptualization and design of the study and participated in data analysis and interpretation; Drs Guttmann and Weintraub supervised the conceptualization and design of the study, and supervised data collection, analysis, and interpretation; and all authors reviewed and revised the manuscript, approved the manuscript as submitted, and agree to be accountable for all aspects of the work.

FUNDING: This work was funded by an internal grant through the Pediatric Scholars Awards Program from the Department of Pediatrics at the Icahn School of Medicine at Mount Sinai. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding department/organization. The funding department/organization had no role in the design, preparation, review, or approval of this paper.

CONFLICT OF INTEREST DISCLOSURES: The authors have indicated they have no potential conflicts of interest relevant to this article to disclose.

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