Although the evidence supporting the efficacy of neuroprotective treatments for hypoxic-ischemic injury in human newborns is limited, efforts to develop effective treatments continue in laboratory studies. In this article, we review some of the treatments that have found their way from the laboratory to clinical studies in newborns. Specifically, the evidence for use of magnesium sulfate, allopurinol, opioids, and hypothermia as possible treatments of hypoxic-ischemic encephalopathy are discussed.
Pharmacology Review: Neuroprotective Treatments for Hypoxic-Ischemic Injury
Drs Marro and Delivoria-Papadopoulos have disclosed no financial relationships relevant to this article. This commentary does contain a discussion of an unapproved/investigative use of a commercial product/device.
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Peter J. Marro, Maria Delivoria-Papadopoulos; Pharmacology Review: Neuroprotective Treatments for Hypoxic-Ischemic Injury. Neoreviews June 2010; 11 (6): e311–e315. https://doi.org/10.1542/neo.11-6-e311
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