Although the evidence supporting the efficacy of neuroprotective treatments for hypoxic-ischemic injury in human newborns is limited, efforts to develop effective treatments continue in laboratory studies. In this article, we review some of the treatments that have found their way from the laboratory to clinical studies in newborns. Specifically, the evidence for use of magnesium sulfate, allopurinol, opioids, and hypothermia as possible treatments of hypoxic-ischemic encephalopathy are discussed.

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