Neonatal lactate elevation is a relatively common finding with heterogeneous causes. Understanding the reason for the lactate elevation is critical to determining the prognosis and treatment options. Lactate can be elevated spuriously, secondary to a number of common neonatal conditions or intermediary inborn errors of metabolism, or as a primary finding in mitochondrial diseases. The extent of the lactate elevation, clinical context, and simple metabolic tests can help differentiate among these causes.
Neonatal Lactic Acidosis: A Diagnostic and Therapeutic Approach
Drs Ganetzky and Cuddapah have disclosed no financial relationships relevant to this article. This commentary does contain a discussion of an unapproved/investigative use of a commercial product/device.
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Rebecca D. Ganetzky, Sanmati R. Cuddapah; Neonatal Lactic Acidosis: A Diagnostic and Therapeutic Approach. Neoreviews April 2017; 18 (4): e217–e227. https://doi.org/10.1542/neo.18-4-e217
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