Perinatal depression, defined as maternal depression that occurs during the antenatal period or the first 12 months after delivery, is a leading cause of maternal morbidity. Although some women may have risk factors for the development of perinatal depression, screening based on risk factors alone is insufficient. In this article, we summarize the validated screening tools that have been used clinically to assess for perinatal depression. We then review the implementation process of universal screening during the obstetric and pediatric office visits and in the setting of the NICU. We conclude that obstetricians, neonatologists, and pediatricians can influence the quality of life for mothers and their children through successful implementation of validated screening tools for perinatal depression.

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