The main purpose of therapeutic cooling is neuroprotection of asphyxiated infants with significant hypoxic-ischemic encephalopathy. However, to improve the overall outcome, it is necessary to properly manage the full range of multiple organ system complications found in asphyxiated infants undergoing therapeutic cooling. Every physiologic process in an asphyxiated infant can potentially be affected by the cooling treatment. The purpose of this review is to discuss the effect of cooling on neonatal physiology in the current recommended cooling range and the management thereof.
Multiple Organ Dysfunction During Therapeutic Cooling of Asphyxiated Infants
Drs Bhagat and Sarkar have disclosed no financial relationships relevant to this article. This commentary does not contain a discussion of an unapproved/investigative use of a commercial product/device.
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Indira Bhagat, Subrata Sarkar; Multiple Organ Dysfunction During Therapeutic Cooling of Asphyxiated Infants. Neoreviews November 2019; 20 (11): e653–e660. https://doi.org/10.1542/neo.20-11-e653
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