Hemophagocytic lymphohistiocytosis (HLH) is extremely rare in the neonatal period. The incidence of neonatal HLH is not confirmed and may range from 1 in 50,000 to 150,000. The incidence varies based on ethnicity, particularly in populations in which consanguinity is common. HLH is associated with a high fatality rate and poor prognosis, making it important to recognize and diagnose it early. This review will concentrate primarily on the diagnosis and management of neonatal HLH.
Neonatal Hemophagocytic Lymphohistiocytosis
Drs McLean, Katebian, Suh, Mirza, and Amin have disclosed no financial relationships relevant to this article. This commentary does not contain a discussion of an unapproved/investigative use of a commercial product/device.
Josef McLean, Roia Katebian, Eugene Suh, Kamran Mirza, Sachin Amin; Neonatal Hemophagocytic Lymphohistiocytosis. Neoreviews June 2019; 20 (6): e316–e325. https://doi.org/10.1542/neo.20-6-e316
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