A female infant is born at 37 weeks’ gestation with diffuse anasarca, high-output cardiac failure and respiratory failure.

Following intubation, the infant was briefly given a milrinone infusion to augment inotropy and packed red blood cell transfusion. Furosemide was initiated, leading to improvement in her edema and respiratory failure. Her lactic acidosis and transaminitis normalized by the 3rd day after birth. She tolerated extubation to continuous positive airway pressure at 72 hours of age. After 4 days of diuresis and supportive care, her anasarca and cardiac function improved. At 11 days of age, brain magnetic resonance imaging (MRI) demonstrated multiple areas of acute infarction in the bilateral corona radiata, periventricular white matter, and splenium of the corpus callosum. Results of all infectious studies and newborn screening were negative. She was discharged 17 days after birth with a normal examination result.

The obstetrician noted abnormal findings on delivery of the placenta...

You do not currently have access to this content.