Preterm infants are born before the critical period of lipid accretion and brain development that occurs during the third trimester of pregnancy. Dietary lipids serve as an important source of energy and are involved in complex processes that are essential for normal central nervous system development. In addition to traditional neurodevelopmental testing, novel quantitative magnetic resonance imaging (MRI) techniques are now available to evaluate the impact of nutritional interventions on early preterm brain development. Trials of long-chain polyunsaturated fatty acid supplementation have yielded inconsistent effects on neurodevelopmental outcomes and quantitative MRI findings. Recent studies using quantitative MRI suggest a positive impact of early lipid intake on brain volumes and white matter microstructural organization by term-equivalent age.
Lipid Intake and Neurodevelopment in Preterm Infants
Drs Ottolini, Andescavage, and Limperopoulos have disclosed no financial relationships relevant to this article. This commentary does not contain a discussion of an unapproved/investigative use of a commercial product/device. The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the Department of Defense or the United States Air Force.
- Views Icon Views
- Share Icon Share
- Search Site
Katherine M. Ottolini, Nickie Andescavage, Catherine Limperopoulos; Lipid Intake and Neurodevelopment in Preterm Infants. Neoreviews June 2021; 22 (6): e370–e381. https://doi.org/10.1542/neo.22-6-e370
Download citation file: