The overall prevalence of opiate use has been increasing, currently affecting approximately 0.6% of the global population and resulting in a significant proportion of infants being born with prenatal opioid exposure. Animal and human models of prenatal opioid exposure demonstrate detrimental effects on brain anatomy as well as neurodevelopment. Less is known about the neurologic sequelae of postnatal opioid exposure in hospitalized infants. In this review, we summarize our current understanding of the impact of prenatal and postnatal opioid exposure on the brain and on neurodevelopment outcomes. We also identify resources and management strategies that may help mitigate neurodevelopmental delays and deficits associated with opioid exposure in this vulnerable population.
Skip Nav Destination
Article navigation
June 2024
Review Articles|
June 01 2024
Developmental Outcomes after Opioid Exposure in the Fetus and Neonate
Jeanette Fong, MD;
Jeanette Fong, MD
*Department of Pediatrics, University of California, Los Angeles, CA
Search for other works by this author on:
Juanita Lewis, MD;
Juanita Lewis, MD
†Department of Pediatrics, Olive View UCLA Medical Center, Sylmar, CA
Search for other works by this author on:
Melanie Lam, PharmD;
Melanie Lam, PharmD
*Department of Pediatrics, University of California, Los Angeles, CA
Search for other works by this author on:
Kalpashri Kesavan, MD
Kalpashri Kesavan, MD
*Department of Pediatrics, University of California, Los Angeles, CA
Search for other works by this author on:
Neoreviews (2024) 25 (6): e325–e337.
Article history
Received:
October 25 2023
Revision Received:
November 05 2023
Accepted:
December 06 2023
Citation
Jeanette Fong, Juanita Lewis, Melanie Lam, Kalpashri Kesavan; Developmental Outcomes after Opioid Exposure in the Fetus and Neonate. Neoreviews June 2024; 25 (6): e325–e337. https://doi.org/10.1542/neo.25-6-e325
Download citation file:
Sign in
Don't already have an account? Register
Purchased this content as a guest? Enter your email address to restore access.
Please enter valid email address.
Pay-Per-View Access
$35.00
Comments