Prader-Willi syndrome (PWS) is a genetic condition that affects the brain and causes newborns and young infants to be weak and slow to gain weight but shifts to causing excessive hunger and weight gain in toddlers. It affects boys and girls equally.

Prader-Willi syndrome occurs at 1 in 15,000 to 30,000 births.

Children with PWS tend to be short and to have obesity, with characteristic facial features. Findings include short stature, incomplete sexual development, intellectual deficits, and behavioral issues. They have obsessive behavior toward foods, which can cause problems, including aggressive behavior and eating inappropriate foods. They can have sleep problems with and without having obesity. Developmental delays are common, including gross-motor and speech delays. Autism spectrum disorder is diagnosed in about 25% of the children. Dry mouth and eye problems can also be seen, as well as hip and spine abnormalities. Obsessive behavior such as skin picking may occur,...

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