1. Recurrent infections from immunodeficiency are much less common than the normal pattern of frequent infections in early childhood.

  2. Immunodeficiency secondary to nonimmunologic causes (eg, cancer, malnutrition, medication/toxin) is more common than primary immunodeficiency.

  3. Common allergic conditions can be confused for recurrent infections: allergic rhinitis for upper respiratory tract infections and asthma for pneumonias.

  4. Children thought to be immunodeficient should not receive live attenuated vaccines (measles-mumps-rubella, rotavirus, varicella, oral poliovirus).

  5. Prompt diagnosis and treatment of children with immunodeficiency can be lifesaving.

Topics:
immunologic deficiency syndromes, primary immune deficiency disorder, recurrent infection, severe combined immunodeficiency, immunoglobulins, intravenous, misdiagnosis, immune deficiency disorder, secondary
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