• Vaginal discharge is caused by infection, inflammation, or changes in the vaginal flora.

  • Vaginal discharge in the prepubertal child can be caused by infection, congenital abnormalities, trauma, or dermatologic conditions.

  • Nonspecific vaginitis is the most common gynecologic problem in the prepubertal child.

  • Prepubertal hypoestrogenic tissues are more susceptible to local irritants, foreign bodies, and infections.

  • Most common causes of vaginitis in postpubertal women are bacterial vaginosis and vaginal candidiasis (Candida vulvovaginitis).

  • Laboratory documentation of etiology of vaginal discharge is mandatory prior to treatment.

  • Target treatment to etiology.

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